A study to learn more about treating malignant mesothelioma - can we improve quality of life?

A multicentre non-blinded

randomised controlled trial to

assess the impact of Regular Early

SPEcialist symptom Control

Treatment on quality of life in

malignant Mesothelioma - “RESPECT-Meso”

A multi-centre non-blinded randomised controlled trial to assess the impact of regular early specialist palliative care treatment on quality of life on malignant mesothelioma

What is this study about?

This study will examine if involving palliative care specialists early in the treatment of mesothelioma improves the quality of life and wellbeing of patients.  We are also interested in how this specialist treatment might affect the wellbeing of family or close friends, closest to patients with this illness.

Why do this study?

Patients with malignant pleural mesothelioma frequently have significant physical symptoms, with more than 90% of patients complaining of three or more symptoms when diagnosed. Such symptoms  are similar to those reported in advanced lung cancer and have been shown to interfere with activity and cause a worse quality of life. Several studies have reported that quality of life at the time of diagnosis can be an important factor for survival in lung cancer patients. In 2010, a randomised trial of 151 patients in the United States demonstrated an improved quality of life, fewer depressive symptoms and improved survival with early, regular specialist palliative care team involvement in addition to their routine care. The RESPECT-Meso study will examine the effect on quality of life following early specialist palliative care involvement in addition to routine care in patients with newly diagnosed MPM in the UK.

More information

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What is


Malignant mesothelioma is a rare cancer of the lining of the chest commonly caused by exposure to asbestos. This exposure may have occurred up to forty years earlier. Mesothelioma usually causes symptoms like breathlessness, loss of weight and chest pain, but it can affect people in different ways. There is no cure for mesothelioma. This study seeks to learn how best we can support patients with mesothelioma and their families.
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